|
KMID : 1101420160480040365
|
|
Korean Journal of Clinical Laboratory Science
2016 Volume.48 No. 4 p.365 ~ p.370
|
|
|
The Anti-Inflammatory Effects of Picea wilsonii Mast on HaCaT Cells
|
|
Cha Kyung-Jae
|
|
|
Abstract
|
|
|
|
Atopic dermatitis refers to a chronic, recurrent, skin condition, typically typified by itching, inflamed skin. It precedes other allergic diseases, such as asthma, food allergies, and allergic rhinitis, and is usually accompanied by various other immune disorders and secondary symptoms. In this study, we discovered that when treating TNF-α and IFN-γ-stimulated HaCaT cells with various concentrations of Picea wilsonii Mast (PwM) extracts, the cell viability was excellent. In addition, we measured the inflammatory cytokines associated with atopic dermatitis, including IL-6, IL-8, IL-13, and MCP-1. The production of IL-6, IL-13, and MCP-1 decreased in the presence of PwM extracts, whereas there was no significant difference in the production of IL-8. Further studies are necessary to develop an effective cure for atopic dermatitis and inflammation using foreign plant extracts, and PwM efficacy should be determined with an in-depth, objective verification process using protein and mechanism analysis.
|
|
|
KEYWORD
|
|
|
Atopic dermatitis, Keratinocytes, Picea, Tumor necrosis factor-alpha
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|